Chemistry is, and always should be, a creative enterprise, providing us with unique and unprecedented innovations to make human society happier, healthier and more sustainable. In addition to being a discovery science, chemistry allows us, through limitless combinations and permutations of the over 100 elements, to create new substances and materials that nature has not yet seen in the 13.5 billion-year history of our universe and to employ them in the betterment of our Earth. We do hope that Pacifichem 2021 will create an active forum and a productive platform where thousands of papers will disclose state-of-the-art, cutting edge findings in chemistry and related multidisciplinary areas that inspire active discussion and opportunities for international collaboration, thereby promoting creativity and a clear creative vision for chemistry.